Chemical Research and Development Department:

Tofigh Daru’s Chemistry R & D laboratories, which were launched in 2004, aim to define new missions in the advancement of API Industry.

This department plays an integral role for the company benefiting from the knowledge and competence of a large number of experienced specialists aiming at the ultimate goals of the company to acquire technological development and optimization, and employing the facilities required for manufacturing of high-quality products. Moreover, it is intended to increase the productivity through continuous improvement of processes and turning technical know-how into wealth. The company has been successful to accomplish projects listed below:

Selecting the latest and most effective active pharmaceutical ingredients and creating technical know-how to produce them

Synthesizing laboratory-scale active pharmaceutical ingredients and developing them in the large scale

Offering technical support for manufacturing difficulties and development of technical solutions

Transferring technical know-how for manufactured products to the other companies

Providing theoretical services for selection and development of pharmaceutical compounds

Accomplished technical know-how projects in the field of manufacturing active pharmaceutical ingredients are as follows:

 

Atracurium Besilate                                                    Aprepitant                                      Aripiprazole

Alprazolam                                                       Alfentanil Hydrochloride                          Imatinib Mesylate

Imipramine                                                                  Baclofen                                  Tolterodine Tartrate

Prasugrel Hydrochloride                                    Dabigatran Etexilate Mesylate                      Desipramine

Deferasirox                                                            Dimethyl Fumarate                        Remifentanil Hydrochloride

Rivastigmine Hydrogen Tartrate                                      Rivaroxaban                                  Zoledronic Acid

Sodium Valproate                                       Sitagliptin Phosphate Monohydrate             Cinacalcet Hydrochloride

Sufentanil Citrate                                               Fluvoxamine Maleate                                Fentanyl Citrate

Fenofibrate                                                  Fingolimod Hydrochloride                                    Letrozole

Clopidogrel                                                          Clomipramine                                            Clonazepam

Gabapentin                                                        Glatiramer Acetate                                      Mesalazine

Memantine Hydrochloride

The reactions that we are expert at:

Enantiomers Separation                  Reduction                            Oxidation

N-alkylation                                O-alkylation                          N- demethylation

N- debenzylation                          Amidation                            Esterification

Coupling reactions                          Nitration                             Cyclization

Isomerization                            Grignard reactions                    Oxime Synthesis

Polymerization